Drouin is a surname. Notable people with the surname include:

• André Drouin, Canadian politician
• Claude Drouin, Canadian politician
• Derek Drouin, Canadian high jumper
• Francis Drouin, Canadian Liberal politician, Member of the Canadian House of Commons
• Henri Drouin (1911–1992), Canadian lawyer, Politician, and judge
• Jacques Drouin (1943–2021), Canadian animator
• Jonathan Drouin, Canadian ice Hockey player
• Jude Drouin, Canadian ice hockey player
• Macy Drouin, voice of Abby Hatcher
• Marie-Josée Drouin, Canadian economist
• Mark Robert Drouin (1903–1963), Canadian politician
• Michelle Drouin, American psychologist
• Noël Drouin (1912–2001), Progressive Conservative party member of the Canadian House of Commons
• Olivier-Napoléon Drouin (1867–1943), Canadian politician, mayor of Quebec City from 1910 to 1916
• Oscar Drouin (1890–1953), Canadian politician
• P. C. Drouin, Canadian ice hockey player for the Fort Wayne Komets
• Paweensuda Drouin, Thai television host, DJ, and beauty pageant titleholder
• Polly Drouin (1908–1968), Canadian ice hockey player
• René Drouin, president and chief executive of the New Hampshire Higher Education Assistance Foundation Network
• Richard Drouin, Canadian lawyer and businessman
• Stéphen Drouin, French footballer
• Vincent Drouin (1932–1979), Liberal party member of the Canadian House of Commons
• Jeff Deslauriers, Canadian ice hockey goaltender